What the FDA labels say about taking them together
Iloperidone and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names iloperidone in its drug interactions section; the iloperidone label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Drug Class: aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, pimavanserin; Drugs within Class: ↑ aripiprazole ↑ brexpiprazole ↑ cariprazine ↑ iloperidone ↑ lumateperone ↑ pimavanserin; …”
Check it at the source: the iloperidone FDA label on DailyMed (effective May 6, 2026, Vanda Pharmaceuticals Inc.); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the iloperidone label say about nirmatrelvir/ritonavir?
Iloperidone's label (effective May 6, 2026) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (FANAPT), Vanda Pharmaceuticals Inc., effective May 6, 2026 (SPL set 33f60b40-3fca-11de-8f56-0002a5d5c51b), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about iloperidone?
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, pimavanserin; Drugs within Class: ↑ aripiprazole ↑ brexpiprazole ↑ cariprazine ↑ iloperidone ↑ lumateperone ↑ pimavanserin; Effect on Concentration: Dosage adjustment of aripiprazole, brexpiprazole, cariprazine, iloperidone, lumateperone, and pimavanserin is recommended. Refer to the individual product prescribing information for more information.
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Iloperidone | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder | COVID-19 |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $60.01 per tablet 12 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once