What the FDA labels say about taking them together
Eplerenone and nirmatrelvir/ritonavir
Nirmatrelvir/ritonavir's FDA label of February 19, 2026 names eplerenone in its contraindications section; the eplerenone label PlainMeds reads does not name nirmatrelvir/ritonavir. The nirmatrelvir/ritonavir label: “Co-administration with eplerenone is contraindicated due to potential for hyperkalemia.”
Check it at the source: the eplerenone FDA label on DailyMed (effective June 23, 2025, Viatris Specialty LLC); the nirmatrelvir/ritonavir FDA label on DailyMed (effective February 19, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the eplerenone label say about nirmatrelvir/ritonavir?
Eplerenone's label (effective June 23, 2025) does not name nirmatrelvir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Inspra), NDA021437 (Upjohn), as published by Viatris Specialty LLC, effective June 23, 2025 (SPL set 1a52bedc-8e2c-4116-a296-a87770676b4a), via openFDA; the full label on DailyMed
What does the nirmatrelvir/ritonavir label say about eplerenone?
Nirmatrelvir/ritonavir label, contraindicationsCardiovascular agents: eplerenone, ivabradine
Nirmatrelvir/ritonavir label, drug interactionsDrug Class: Cardiovascular agents; Drugs within Class: eplerenone; Effect on Concentration: ↑ eplerenone; Clinical Comments: Co-administration with eplerenone is contraindicated due to potential for hyperkalemia [see ].
Source: FDA drug label (Paxlovid), Pfizer Laboratories Div Pfizer Inc, effective February 19, 2026 (SPL set 8a99d6d6-fd9e-45bb-b1bf-48c7f761232a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Eplerenone | Nirmatrelvir/ritonavir | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure | COVID-19 |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.308 per tablet 25 mg tablet | $49.24 per unit 300-100 mg dose pack |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once