What the FDA labels say about taking them together
Nifedipine and propranolol
Propranolol's FDA label of January 15, 2026 names nifedipine in its drug interactions section; nifedipine's label does not name propranolol itself but warns about its class (Beta blockers). The propranolol label: “The mean C max and AUC of nifedipine are increased by 64% and 79%, respectively, by co-administration of propranolol.”
Check it at the source: the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the nifedipine label say about propranolol?
Nifedipine's label does not name propranolol itself; it warns about its class (Beta blockers):
Nifedipine label, warningsSevere hypotension and/or increased fluid volume requirements have been reported in patients who received immediate release capsules together with a beta-blocking agent and who underwent coronary artery bypass surgery using high dose fentanyl anesthesia. The interaction with high dose fentanyl appears to be due to the combination of nifedipine and a beta-blocker, but the possibility that it may occur with nifedipine alone, with low doses of fentanyl, in other surgical procedures, or with other narcotic analgesics …
Nifedipine label, drug interactionsDrug Interactions Beta-adrenergic blocking agents (see INDICATIONS AND USAGE and WARNINGS ) Experience in over 1400 patients with PROCARDIA capsules in a noncomparative clinical trial has shown that concomitant administration of nifedipine and beta-blocking agents is usually well tolerated, but there have been occasional literature reports suggesting that the combination may increase the likelihood of congestive heart failure, severe hypotension, or exacerbation of angina.
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
What does the propranolol label say about nifedipine?
Propranolol label, drug interactionsThe mean C max and AUC of nifedipine are increased by 64% and 79%, respectively, by co-administration of propranolol.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nifedipine | Propranolol | |
|---|---|---|
| Labeled for | High blood pressure, Angina | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.130 per tablet 30 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once