What the FDA labels say about taking them together
Nelfinavir and sirolimus
Nelfinavir's FDA label of December 11, 2025 names sirolimus in its drug interactions section; the sirolimus labels PlainMeds reads (4) do not name nelfinavir. The nelfinavir label: “Concentrations of these immunosuppressants and nelfinavir may be increased by coadministration of these agents with nelfinavir.”
Check it at the source: the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON); the sirolimus FDA label on DailyMed (effective January 28, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the nelfinavir label say about sirolimus?
Nelfinavir label, drug interactionsConcomitant Drug Class/Drug Name: Cyclosporine Tacrolimus Sirolimus; Effect on Concentration: ↑ immuno-suppressants ↑ nelfinavir; Clinical Comment: Concentrations of these immunosuppressants and nelfinavir may be increased by coadministration of these agents with nelfinavir.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
What does the sirolimus label say about nelfinavir?
Sirolimus's label (effective January 28, 2026) and its 3 other brand-application labels do not name nelfinavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (sirolimus), Glenmark Pharmaceuticals Inc., USA, effective January 28, 2026 (SPL set 57fb4d90-3ccb-4a69-af1e-53be83f7a504), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nelfinavir | Sirolimus | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.723 per tablet 1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once