What the FDA labels say about taking them together
Nelfinavir and omeprazole
Nelfinavir's FDA label of December 11, 2025 names omeprazole in its drug interactions section, and omeprazole's label names nelfinavir too. The omeprazole label: “The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. …”
Check it at the source: the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON); the omeprazole FDA label on DailyMed (effective April 22, 2024, Apotex Corp).
What does the nelfinavir label say about omeprazole?
Nelfinavir label, drug interactionsConcomitant Drug Class/Drug Name: Omeprazole; Effect on Concentration: ↓ nelfinavir; Clinical Comment: Omeprazole decreases the plasma concentrations of nelfinavir. Concomitant use of proton pump inhibitors and VIRACEPT may lead to a loss of virologic response and development of resistance.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
What does the omeprazole label say about nelfinavir?
Omeprazole label, drug interactionsAntiretrovirals Clinical Impact: The effect of PPIs on antiretroviral drugs is variable. The clinical importance and the mechanisms behind these interactions are not always known. Decreased exposure of some antiretroviral drugs (…) when used concomitantly with omeprazole may reduce antiviral effect and promote the development of drug resistance. … Intervention: Rilpivirine-containing products: Concomitant use with omeprazole is contraindicated [see Contraindications ()]. Atazanavir: Avoid concomitant use with omeprazole. See prescribing information for atazanavir for dosing information. Nelfinavir: Avoid concomitant use with omeprazole. …
Source: FDA drug label (Omeprazole), Apotex Corp, effective April 22, 2024 (SPL set b83329ac-a65e-b3af-a3fb-c5a6c740e5e7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nelfinavir | Omeprazole | |
|---|---|---|
| Labeled for | HIV | Acid reflux and ulcers |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.0295 per capsule 20 mg capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once