What the FDA labels say about taking them together
Nelfinavir and nifedipine
Nifedipine's FDA label of December 24, 2024 names nelfinavir in its drug interactions section; nelfinavir's label does not name nifedipine itself but warns about its class (Calcium channel blockers (dihydropyridines)). The nifedipine label: “… erythromycin, grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.”
Check it at the source: the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON); the nifedipine FDA label on DailyMed (effective December 24, 2024, Aurobindo Pharma Limited).
What does the nelfinavir label say about nifedipine?
Nelfinavir's label does not name nifedipine itself; it warns about its class (Calcium channel blockers (dihydropyridines)):
Nelfinavir label, drug interactionsCoadministration of VIRACEPT and drugs primarily metabolized by CYP3A (e.g., dihydropyridine calcium channel blockers, HMG-CoA reductase inhibitors, immunosuppressants, and PDE5 inhibitors) may result in increased plasma concentrations of such drugs that could increase or prolong both its therapeutic and adverse effects (see Tables 3 and 6 ).
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
What does the nifedipine label say about nelfinavir?
Nifedipine label, drug interactionsCYP3A inhibitors CYP3A inhibitors such as ketoconazole, fluconazole, itraconazole, clarithromycin, erythromycin (Azithromycin, although structurally related to the class of macrolide antibiotic is void of clinically relevant CYP3A4 inhibition), grapefruit, nefazodone, fluoxetine, saquinavir, indinavir, nelfinavir, and ritonavir may result in increased exposure to nifedipine when co-administered.
Procardia Xl label (Pfizer Laboratories Div Pfizer Inc, December 16, 2025), drug interactionsCYP3A inhibitors such as fluconazole, itraconazole, clarithromycin, erythromycin, nefazodone, fluoxetine, saquinavir, indinavir, and nelfinavir may result in increased exposure to nifedipine when co-administered.
Source: FDA drug label (Procardia Xl, NDA019684), Pfizer Laboratories Div Pfizer Inc, effective December 16, 2025 (SPL set 8ebcb33c-f43b-4b36-9f94-9774b2a59e06), via openFDA
Source: FDA drug label (Nifedipine), Aurobindo Pharma Limited, effective December 24, 2024 (SPL set eb70b7ff-f9f0-41d0-901a-f4c04ae9ed46), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nelfinavir | Nifedipine | |
|---|---|---|
| Labeled for | HIV | High blood pressure, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.130 per tablet 30 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once