What the FDA labels say about taking them together
Nefazodone and suvorexant
Suvorexant's FDA label of March 10, 2025 names nefazodone in its drug interactions section; the nefazodone label PlainMeds reads does not name suvorexant. The suvorexant label: “CYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A is not recommended.”
Check it at the source: the nefazodone FDA label on DailyMed (effective July 31, 2025, Teva Pharmaceuticals USA, Inc.); the suvorexant FDA label on DailyMed (effective March 10, 2025, Merck Sharp & Dohme LLC).
What does the nefazodone label say about suvorexant?
Nefazodone's label (effective July 31, 2025) does not name suvorexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nefazodone Hydrochloride), Teva Pharmaceuticals USA, Inc., effective July 31, 2025 (SPL set 51ff7db5-aaf9-4c3c-86e6-958ebf16b60f), via openFDA; the full label on DailyMed
What does the suvorexant label say about nefazodone?
Suvorexant label, drug interactionsCYP3A Inhibitors Concomitant use of BELSOMRA with strong inhibitors of CYP3A (e.g., ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin and conivaptan) is not recommended [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (BELSOMRA), Merck Sharp & Dohme LLC, effective March 10, 2025 (SPL set e5b72731-1acb-45b7-9c13-290ad12d3951), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Nefazodone | Suvorexant | |
|---|---|---|
| Labeled for | Depression | Insomnia |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.17 per tablet 100 mg tablet | $15.21 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once