What the FDA labels say about taking them together
Naproxen and probenecid
Naproxen's FDA label of March 12, 2026 names probenecid in its drug interactions (prescription label) section, and probenecid's label names naproxen too. The naproxen label: “Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly.”
Check it at the source: the naproxen FDA label on DailyMed (effective March 12, 2026, Bayer HealthCare LLC.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the naproxen label say about probenecid?
Naproxen label, drug interactions (prescription label)Clinical Impact: Probenecid given concurrently increases naproxen anion plasma levels and extends its plasma half-life significantly. Intervention: Patients simultaneously receiving naproxen tablets or naproxen sodium tablets and probenecid should be observed for adjustment of dose if required. Other albumin-bound drugs
Source: FDA drug label (Naprelan, NDA020353), Upsher-Smith Laboratories, LLC, effective January 8, 2026 (SPL set b8a51c9a-488e-4377-a041-436f6a2f8893), via openFDA
Source: FDA drug label (Naproxen, NDA018965), Acella Pharmaceuticals, LLC, effective January 5, 2026 (SPL set 7e6f03fb-4b36-4418-9684-f45637abbb78), via openFDA
Source: FDA drug label (Naproxen, NDA020067), Zameer Pharmaceuticals LLC, effective August 23, 2025 (SPL set d2e5553a-7c90-407c-9f07-3be65560c23a), via openFDA
Source: FDA drug label (Aleve Caplets), Bayer HealthCare LLC., effective March 12, 2026 (SPL set 02941928-128a-2c88-e063-6294a90ac6ba), via openFDA; the full label on DailyMed
What does the probenecid label say about naproxen?
Probenecid label, drug interactionsThese include agents such as indomethacin, acetaminophen, naproxen, ketoprofen, meclofenamate, lorazepam, and rifampin.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Naproxen | Probenecid | |
|---|---|---|
| Labeled for | Fever, Rheumatoid arthritis, Osteoarthritis, Gout, Pain, Cough and cold | Gout |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0565 per tablet 500 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once