What the FDA labels say about taking them together
Digoxin and naproxen
Naproxen's FDA label of March 12, 2026 names digoxin in its drug interactions (prescription label) section; the digoxin labels PlainMeds reads (3) do not name naproxen. The naproxen label: “The concomitant use of naproxen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the naproxen FDA label on DailyMed (effective March 12, 2026, Bayer HealthCare LLC.).
What does the digoxin label say about naproxen?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name naproxen in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the naproxen label say about digoxin?
Naproxen label, drug interactions (prescription label)Clinical Impact: The concomitant use of naproxen with digoxin has been reported to increase the serum concentration and prolong the half-life of digoxin. Intervention: During concomitant use of naproxen tablets or naproxen sodium tablets and digoxin, monitor serum digoxin levels.
Source: FDA drug label (Naprelan, NDA020353), Upsher-Smith Laboratories, LLC, effective January 8, 2026 (SPL set b8a51c9a-488e-4377-a041-436f6a2f8893), via openFDA
Source: FDA drug label (Naproxen, NDA018965), Acella Pharmaceuticals, LLC, effective January 5, 2026 (SPL set 7e6f03fb-4b36-4418-9684-f45637abbb78), via openFDA
Source: FDA drug label (Naproxen, NDA020067), Zameer Pharmaceuticals LLC, effective August 23, 2025 (SPL set d2e5553a-7c90-407c-9f07-3be65560c23a), via openFDA
Source: FDA drug label (Aleve Caplets), Bayer HealthCare LLC., effective March 12, 2026 (SPL set 02941928-128a-2c88-e063-6294a90ac6ba), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Naproxen | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Fever, Rheumatoid arthritis, Osteoarthritis, Gout, Pain, Cough and cold |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | $0.0565 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once