Morphine and Linezolid Interaction
Drug interaction information between Morphine and Linezolid.
Morphine and Linezolid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Morphine and Linezolid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Linezolid acts as a monoamine oxidase inhibitor, which stops the body from breaking down serotonin. This can cause serotonin to reach dangerous levels when taken with morphine.
FDA Label Information
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Examples: Phenelzine, tranylcypromine, linezolid.
Morphine Also Interacts With
- Trazodone minor
- Tramadol minor
- Cyclobenzaprine minor
- Mirtazapine minor
- Verapamil minor
Linezolid Also Interacts With
- Citalopram major
- Escitalopram major
- Mirtazapine major
- Paroxetine major
- Safinamide major
Frequently Asked Questions
What SPL severity band is on file for Morphine + Linezolid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Morphine has 30 labeled pairs on file vs Linezolid's 29. In the minor band specifically: Morphine has 30 (also Trazodone, Tramadol, Cyclobenzaprine, Mirtazapine); Linezolid has 18 (also Acetaminophen/Oxycodone, Buprenorphine, Buprenorphine/Naloxone, Buprenorphine).
What mechanism field is on file for Morphine and Linezolid?
Linezolid acts as a monoamine oxidase inhibitor, which stops the body from breaking down serotonin. This can cause serotonin to reach dangerous levels when taken with morphine.
Linezolid carries more major-labeled pairs than Morphine
SPL source-record counts only. This page's band is minor · classes on file: Morphine (Opioid Analgesic); Linezolid (Oxazolidinone Antibiotic).
Linezolid has 8 major-labeled pairs vs Morphine's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 30 minor · 30 total
- Other minor peers for Morphine
- Trazodone
- Tramadol
- Cyclobenzaprine
- Mirtazapine
8 major · 3 moderate · 18 minor · 29 total
- Other minor peers for Linezolid
- Acetaminophen/Oxycodone
- Buprenorphine
- Buprenorphine/Naloxone
- Buprenorphine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.