What the FDA labels say about taking them together
Mitotane and warfarin
Mitotane's FDA label of March 3, 2026 names warfarin in its drug interactions section; the warfarin label PlainMeds reads does not name mitotane. The mitotane label: “Warfarin Mitotane may induce the metabolism of warfarin, which may reduce its level and its efficacy.”
Check it at the source: the mitotane FDA label on DailyMed (effective March 3, 2026, ESTEVE PHARMACEUTICALS, S.A.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the mitotane label say about warfarin?
Mitotane label, drug interactionsWarfarin Mitotane may induce the metabolism of warfarin, which may reduce its level and its efficacy [see Clinical Pharmacology (12.3) ].
Source: FDA drug label (Lysodren), ESTEVE PHARMACEUTICALS, S.A., effective March 3, 2026 (SPL set 4046a224-8832-daa2-e063-6294a90a11d7), via openFDA; the full label on DailyMed
What does the warfarin label say about mitotane?
Warfarin's label (effective May 29, 2026) does not name mitotane in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mitotane | Warfarin | |
|---|---|---|
| Labeled for | n/a | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once