Metronidazole and Disulfiram Interaction
Drug interaction information between Metronidazole and Disulfiram.
Metronidazole and Disulfiram have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Metronidazole and Disulfiram. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Combining these two medicines can cause serious mental health problems, such as confusion or psychotic reactions.
FDA Label Information
Drug Interactions Disulfiram Psychotic reactions have been reported in alcoholic patients who are using metronidazole and disulfiram concurrently. Metronidazole should not be given to patients who have taken disulfiram within the last two weeks (see CONTRAINDICATIONS ).
Metronidazole Also Interacts With
- Theophylline major
- Lithium minor
- Cimetidine minor
- Phenytoin minor
- Phenobarbital minor
Disulfiram Also Interacts With
- Phenytoin moderate
- Acamprosate minor
- Amitriptyline minor
- Nabilone minor
- Naltrexone minor
Frequently Asked Questions
What SPL severity band is on file for Metronidazole + Disulfiram?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metronidazole has 10 labeled pairs on file vs Disulfiram's 8. In the minor band specifically: Metronidazole has 9 (also Lithium, Cimetidine, Phenytoin, Phenobarbital); Disulfiram has 7 (also Acamprosate, Amitriptyline, Nabilone, Naltrexone).
What mechanism field is on file for Metronidazole and Disulfiram?
Combining these two medicines can cause serious mental health problems, such as confusion or psychotic reactions.
Metronidazole carries more major-labeled pairs than Disulfiram
SPL source-record counts only. This page's band is minor · classes on file: Metronidazole (Nitroimidazole Antibiotic); Disulfiram (Aldehyde Dehydrogenase Inhibitor).
Metronidazole has 1 major-labeled pair vs Disulfiram's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 9 minor · 10 total
- Other minor peers for Metronidazole
- Lithium
- Cimetidine
- Phenytoin
- Phenobarbital
0 major · 1 moderate · 7 minor · 8 total
- Other minor peers for Disulfiram
- Acamprosate
- Amitriptyline
- Nabilone
- Naltrexone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.