What the FDA labels say about taking them together
Disulfiram and metronidazole
Disulfiram's FDA label of August 20, 2024 names metronidazole in its contraindications section, and metronidazole's label names disulfiram too. The metronidazole label: “Do not administer Metronidazole Injection to patients who have taken disulfiram within the last two weeks (see CONTRAINDICATIONS ).”
Check it at the source: the disulfiram FDA label on DailyMed (effective August 20, 2024, Sigmapharm Laboratories, LLC); the metronidazole FDA label on DailyMed (effective September 3, 2024, Aurobindo Pharma Limited).
What does the disulfiram label say about metronidazole?
Disulfiram label, contraindicationsCONTRAINDICATIONS: Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.g., cough syrups, tonics and the like, should not be given disulfiram.
Source: FDA drug label (Disulfiram), Sigmapharm Laboratories, LLC, effective August 20, 2024 (SPL set 40f5497f-fe84-43b2-8ff4-32d59edf3917), via openFDA; the full label on DailyMed
What does the metronidazole label say about disulfiram?
Metronidazole label, contraindicationsPsychotic Reaction with Disulfiram Use of oral metronidazole is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently.
Metronidazole label, drug interactionsMetronidazole should not be given to patients who have taken disulfiram within the last two weeks (see CONTRAINDICATIONS ).
Source: FDA drug label (Flagyl, NDA020334), Pfizer Laboratories Div Pfizer Inc, effective May 22, 2026 (SPL set a2883ca1-5a9a-4259-9d80-46ab67274384), via openFDA
Source: FDA drug label (Metronidazole, NDA018900), B. Braun Medical Inc., effective April 23, 2026 (SPL set fd191c06-9d3b-4e46-9f79-90f6af614947), via openFDA
Source: FDA drug label (Metronidazole), Aurobindo Pharma Limited, effective September 3, 2024 (SPL set f68397ee-67db-472e-8607-4300064e37df), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Disulfiram | Metronidazole | |
|---|---|---|
| Labeled for | Alcohol use disorder | Bacterial infections |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $1.82 per tablet 250 mg tablet | $0.102 per tablet 250 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once