What the FDA labels say about taking them together
Methylergonovine and nelfinavir
Methylergonovine's FDA label of May 1, 2026 names nelfinavir in its drug interactions section, and nelfinavir's label names methylergonovine too. The nelfinavir label: “Potential for serious and/or life threatening reactions such as ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues.”
Check it at the source: the methylergonovine FDA label on DailyMed (effective May 1, 2026, Teva Pharmaceuticals USA, Inc.); the nelfinavir FDA label on DailyMed (effective December 11, 2025, AGOURON).
What does the methylergonovine label say about nelfinavir?
Methylergonovine label, drug interactionsAlthough there have been no reports of such interactions with methylergonovine alone, strong and moderate CYP 3A4 inhibitors should not be coadministered with methylergonovine. Examples of some of the strong CYP 3A4 inhibitors include saquinavir, grapefruit juice, nefazodone, macrolide antibiotics (e.g., troleandomycin, clarithromycin), HIV protease or reverse transcriptase inhibitors (e.g., ritonavir, indinavir, nelfinavir) or azole antifungals (e.g., ketoconazole, itraconazole, voriconazole). Moderate inhibitors include fluconazole, fluvoxamine and clotrimazole.
Source: FDA drug label (Methylergonovine Maleate), Teva Pharmaceuticals USA, Inc., effective May 1, 2026 (SPL set d8e4b8ed-3289-4611-8a61-2392a4bf6072), via openFDA; the full label on DailyMed
What does the nelfinavir label say about methylergonovine?
Nelfinavir label, contraindicationsDrug Class: Ergot Derivatives; Drugs Within Class That Are Contraindicated With VIRACEPT: Dihydroergotamine, ergotamine, methylergonovine; Clinical Comment: Potential for serious and/or life threatening reactions such as ergot toxicity characterized by peripheral vasospasm and ischemia of the extremities and other tissues.
Source: FDA drug label (VIRACEPT), AGOURON, effective December 11, 2025 (SPL set e72c2bc6-9462-4a2e-8e1d-b97592376cbd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methylergonovine | Nelfinavir | |
|---|---|---|
| Labeled for | n/a | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $4.50 per tablet 0.2 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once