What the FDA labels say about taking them together
Methyldopa and phenelzine
Phenelzine's FDA label of June 6, 2025 names methyldopa in its contraindications section; the methyldopa label PlainMeds reads does not name phenelzine.
Check it at the source: the methyldopa FDA label on DailyMed (effective March 26, 2025, Chartwell RX, LLC); the phenelzine FDA label on DailyMed (effective June 6, 2025, Parke-Davis Div of Pfizer Inc).
What does the methyldopa label say about phenelzine?
Methyldopa's label (effective March 26, 2025) does not name phenelzine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methyldopa), Chartwell RX, LLC, effective March 26, 2025 (SPL set e1114a58-9ab5-486e-85ed-360365b06396), via openFDA; the full label on DailyMed
What does the phenelzine label say about methyldopa?
Phenelzine label, contraindicationsTherefore, patients being treated with NARDIL should not take sympathomimetic drugs (including amphetamines, cocaine, methylphenidate, dopamine, epinephrine, and norepinephrine) or related compounds (including methyldopa, L-dopa, L-tryptophan, L-tyrosine, and phenylalanine).
Source: FDA drug label (Nardil), Parke-Davis Div of Pfizer Inc, effective June 6, 2025 (SPL set 513a41d0-37d4-4355-8a6d-a2c643bce6fa), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Methyldopa | Phenelzine | |
|---|---|---|
| Labeled for | n/a | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.586 per tablet 15 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once