What the FDA labels say about taking them together
Mesalamine and sulfasalazine
Mesalamine's FDA label of August 27, 2026 names sulfasalazine in its warnings and precautions section; the sulfasalazine label PlainMeds reads does not name mesalamine.
Check it at the source: the mesalamine FDA label on DailyMed (effective August 27, 2026, Salix Pharmaceuticals, Inc.); the sulfasalazine FDA label on DailyMed (effective May 29, 2026, Pfizer Laboratories Div Pfizer Inc).
What does the mesalamine label say about sulfasalazine?
Mesalamine label, warnings and precautionsAs with sulfasalazine, mesalamine-induced hypersensitivity reactions may present as internal organ involvement, including myocarditis, pericarditis, nephritis, hepatitis, pneumonitis and hematologic abnormalities.
Source: FDA drug label (APRISO), Salix Pharmaceuticals, Inc., effective August 27, 2026 (SPL set 7951139c-b271-45a4-b523-34b23800917b), via openFDA; the full label on DailyMed
What does the sulfasalazine label say about mesalamine?
Sulfasalazine's label (effective May 29, 2026) does not name mesalamine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Azulfidine), Pfizer Laboratories Div Pfizer Inc, effective May 29, 2026 (SPL set ddbe69f3-bd55-45f3-a64f-f60226c744c4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mesalamine | Sulfasalazine | |
|---|---|---|
| Labeled for | Crohn's disease and ulcerative colitis | Crohn's disease and ulcerative colitis, Rheumatoid arthritis |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.781 per tablet 1.2 g tablet | $0.199 per tablet 500 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once