What the FDA labels say about taking them together
Meropenem and probenecid
Meropenem's FDA label of July 16, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name meropenem. The meropenem label: “DRUG INTERACTIONS Co-administration of Meropenem for Injection with probenecid inhibits renal excretion of meropenem and is therefore not recommended. …”
Check it at the source: the meropenem FDA label on DailyMed (effective July 16, 2025, Eugia US LLC); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the meropenem label say about probenecid?
Meropenem label, drug interactionsDRUG INTERACTIONS Co-administration of Meropenem for Injection with probenecid inhibits renal excretion of meropenem and is therefore not recommended. ( 7.1 ) The concomitant use of Meropenem and valproic acid or divalproex sodium is generally not recommended.
Meropenem label (WG Critical Care, LLC, September 8, 2026), drug interactionsCo-administration of meropenem for injection with probenecid inhibits renal excretion of meropenem and therefore Meropenem for Injection is not recommended
Source: FDA drug label (Meropenem, NDA215212), WG Critical Care, LLC, effective September 8, 2026 (SPL set 240325ba-47a8-4ad1-bcab-6772069ee790), via openFDA
Source: FDA drug label (Meropenem), Eugia US LLC, effective July 16, 2025 (SPL set bf1d3433-9e3f-40a0-8bff-c8ceaa8bab7c), via openFDA; the full label on DailyMed
What does the probenecid label say about meropenem?
Probenecid's label (effective January 5, 2021) does not name meropenem in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Meropenem | Probenecid | |
|---|---|---|
| Labeled for | n/a | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $4.69 per vial 1 g vial | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once