Meperidine and Pregabalin Interaction
Drug interaction information between Meperidine and Pregabalin.
Meperidine and Pregabalin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Meperidine and Pregabalin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These drugs both have a calming effect on the brain and nerves. Taking them together can cause you to feel very sleepy or have trouble breathing.
FDA Label Information
Examples: Benzodiazepines and other sedatives/hypnotics, anxiolytics, tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), other opioids, alcohol.
Meperidine Also Interacts With
- Safinamide major
- Rasagiline moderate
- Tranylcypromine moderate
- Gabapentin minor
- Trazodone minor
Pregabalin Also Interacts With
- Acetaminophen/Oxycodone moderate
- Lamotrigine minor
- Topiramate minor
- Lorazepam minor
- Carbamazepine minor
Frequently Asked Questions
What SPL severity band is on file for Meperidine + Pregabalin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meperidine has 31 labeled pairs on file vs Pregabalin's 14. In the minor band specifically: Meperidine has 28 (also Gabapentin, Trazodone, Tramadol, Cyclobenzaprine); Pregabalin has 13 (also Lamotrigine, Topiramate, Lorazepam, Carbamazepine).
What mechanism field is on file for Meperidine and Pregabalin?
These drugs both have a calming effect on the brain and nerves. Taking them together can cause you to feel very sleepy or have trouble breathing.
Meperidine carries more major-labeled pairs than Pregabalin
SPL source-record counts only. This page's band is minor · classes on file: Meperidine (Opioid Analgesic); Pregabalin (Anticonvulsant / Nerve Pain Agent).
Meperidine has 1 major-labeled pair vs Pregabalin's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 28 minor · 31 total
- Other minor peers for Meperidine
- Gabapentin
- Trazodone
- Tramadol
- Cyclobenzaprine
0 major · 1 moderate · 13 minor · 14 total
- Other minor peers for Pregabalin
- Lamotrigine
- Topiramate
- Lorazepam
- Carbamazepine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.