What the FDA labels say about taking them together
Melphalan and warfarin
Melphalan's FDA label (Hepzato Kit) of June 9, 2026 names warfarin in its warnings and precautions section; the warfarin label PlainMeds reads does not name melphalan. The melphalan label: “Discontinue anticoagulation with warfarin or other oral anticoagulants prior to the procedure; resume when hemostasis has been restored after the procedure, provided no bleeding complications have been observed.”
Check it at the source: the melphalan FDA label on DailyMed (effective July 7, 2026, Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.); the warfarin FDA label on DailyMed (effective May 29, 2026, Amneal Pharmaceuticals LLC).
What does the melphalan label say about warfarin?
Hepzato Kit label (Delcath Systems, Inc., June 9, 2026), warnings and precautionsDiscontinue anticoagulation with warfarin or other oral anticoagulants prior to the procedure; resume when hemostasis has been restored after the procedure, provided no bleeding complications have been observed.
Source: FDA drug label (Hepzato Kit, NDA201848), Delcath Systems, Inc., effective June 9, 2026 (SPL set 4f83c8f7-4cc0-4219-88d5-7cfddce91198), via openFDA
Source: FDA drug label (Melphalan hydrochloride), Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc., effective July 7, 2026 (SPL set 2c18beeb-7bd4-4591-94cb-9d7156c1b8e0), via openFDA; the full label on DailyMed
What does the warfarin label say about melphalan?
Warfarin's label (effective May 29, 2026) does not name melphalan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Warfarin Sodium), Amneal Pharmaceuticals LLC, effective May 29, 2026 (SPL set 558b7a0d-5490-4c1b-802e-3ab3f1efe760), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Melphalan | Warfarin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Blood clots (DVT and PE), Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.093 per tablet 2 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once