What the FDA labels say about taking them together
Mefloquine and ziprasidone
Ziprasidone's FDA label of July 20, 2026 names mefloquine in its contraindications section; the mefloquine label PlainMeds reads does not name ziprasidone. The ziprasidone label: “… droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. …”
Check it at the source: the mefloquine FDA label on DailyMed (effective November 18, 2024, Chartwell RX, LLC); the ziprasidone FDA label on DailyMed (effective July 20, 2026, Apotex Corp.).
What does the mefloquine label say about ziprasidone?
Mefloquine's label (effective November 18, 2024) does not name ziprasidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mefloquine Hydrochloride), Chartwell RX, LLC, effective November 18, 2024 (SPL set b884d22b-aae7-4f14-9a04-ae4029a229f0), via openFDA; the full label on DailyMed
What does the ziprasidone label say about mefloquine?
Ziprasidone label, contraindicationsTherefore, ziprasidone should not be given with: dofetilide, sotalol, quinidine, other Class Ia and III anti-arrhythmics, mesoridazine, thioridazine, chlorpromazine, droperidol, pimozide, sparfloxacin, gatifloxacin, moxifloxacin, halofantrine, mefloquine, pentamidine, arsenic trioxide, levomethadyl acetate, dolasetron mesylate, probucol or tacrolimus. other drugs that have demonstrated QT prolongation as one of their pharmacodynamic effects and have this effect described in the full prescribing information as a contraindication or a boxed or bolded warning [see Warnings and Precautions (5.3) ].
Source: FDA drug label (ziprasidone hydrochloride), Apotex Corp., effective July 20, 2026 (SPL set ccfd5ba2-7271-f3dd-4c98-7418c1a4b54a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mefloquine | Ziprasidone | |
|---|---|---|
| Labeled for | n/a | Bipolar disorder, Schizophrenia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $3.97 per tablet 250 mg tablet | $0.269 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once