What the FDA labels say about taking them together
Indomethacin and mefenamic acid
Mefenamic acid's FDA label of April 20, 2026 names indomethacin in its drug interactions section; indomethacin's label does not name mefenamic acid itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)).
Check it at the source: the indomethacin FDA label on DailyMed (effective December 19, 2025, Glenmark Pharmaceuticals Inc., USA); the mefenamic acid FDA label on DailyMed (effective April 20, 2026, Lupin Pharmaceuticals, Inc.).
What does the indomethacin label say about mefenamic acid?
Indomethacin's label does not name mefenamic acid itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Indomethacin label, boxed warningGastrointestinal Bleeding, Ulceration, and Perforation NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Indomethacin label, boxed warningThis risk may occur early in treatment and may increase with duration of use ( 5.1 ) INDOCIN is contraindicated in the setting of coronary artery bypass graft (CABG) surgery ( 4 , 5.1 ) NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.
Source: FDA drug label (Indomethacin), Glenmark Pharmaceuticals Inc., USA, effective December 19, 2025 (SPL set f7ed39e2-5431-4e47-935c-c7441d058f94), via openFDA; the full label on DailyMed
What does the mefenamic acid label say about indomethacin?
Mefenamic acid label, drug interactionsNSAIDs with short elimination half-lives (e.g., diclofenac, indomethacin) should be avoided for a period of two days before, the day of, and two days following administration of pemetrexed.
Source: FDA drug label (Mefenamic Acid), Lupin Pharmaceuticals, Inc., effective April 20, 2026 (SPL set d15733a9-d5fd-4d5f-86ce-e7ed8c706c7f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Indomethacin | Mefenamic acid | |
|---|---|---|
| Labeled for | Rheumatoid arthritis, Osteoarthritis | Pain |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.210 per capsule 75 mg capsule | $0.948 per capsule 250 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once