What the FDA labels say about taking them together
Mebendazole and metronidazole
Mebendazole's FDA label of October 5, 2021 names metronidazole in its drug interactions section; the metronidazole labels PlainMeds reads (4) do not name mebendazole. The mebendazole label: “Monitor blood counts in these patients Metronidazole and Serious Skin Reactions: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have been reported with the concomitant use of mebendazole and metronidazole.”
Check it at the source: the mebendazole FDA label on DailyMed (effective October 5, 2021, Janssen Pharmaceuticals, Inc.); the metronidazole FDA label on DailyMed (effective September 3, 2024, Aurobindo Pharma Limited).
What does the mebendazole label say about metronidazole?
Mebendazole label, drug interactionsDRUG INTERACTIONS Concomitant use of mebendazole and metronidazole should be avoided [see Warnings and Precautions (5.3) ].
Mebendazole label, warnings and precautionsMonitor blood counts in these patients ( 5.2 ) Metronidazole and Serious Skin Reactions: Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) have been reported with the concomitant use of mebendazole and metronidazole.
Source: FDA drug label (VERMOX), Janssen Pharmaceuticals, Inc., effective October 5, 2021 (SPL set a720c424-517a-461b-8e13-6c37caf8aa3f), via openFDA; the full label on DailyMed
What does the metronidazole label say about mebendazole?
Metronidazole's label (effective September 3, 2024) and its 3 other brand-application labels do not name mebendazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Metronidazole), Aurobindo Pharma Limited, effective September 3, 2024 (SPL set f68397ee-67db-472e-8607-4300064e37df), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Mebendazole | Metronidazole | |
|---|---|---|
| Labeled for | n/a | Bacterial infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.102 per tablet 250 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once