What the FDA labels say about taking them together
Lurasidone and phenytoin
Lurasidone's FDA label of January 31, 2025 names phenytoin in its contraindications section; the phenytoin labels PlainMeds reads (2) do not name lurasidone. The lurasidone label: “Concomitant use of LATUDA with strong CYP3A4 inducers decreased the exposure of lurasidone compared to the use of LATUDA alone.”
Check it at the source: the lurasidone FDA label on DailyMed (effective January 31, 2025, Sumitomo Pharma America, Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the lurasidone label say about phenytoin?
Lurasidone label, contraindicationsStrong CYP3A4 inducers (e.g., rifampin, avasimibe, St. John's wort, phenytoin, carbamazepine, etc.) [see Drug Interactions ( 7.1 )].
Lurasidone label, drug interactionsStrong CYP3A4 Inducers Clinical Impact: Concomitant use of LATUDA with strong CYP3A4 inducers decreased the exposure of lurasidone compared to the use of LATUDA alone. Intervention: LATUDA should not be used concomitantly with strong CYP3A4 inducers [see Contraindications ()]. Examples: Rifampin, avasimibe, St. John's wort, phenytoin, carbamazepine
Source: FDA drug label (Latuda), NDA200603 (Sunovion Pharms Inc), as published by Sumitomo Pharma America, Inc., effective January 31, 2025 (SPL set afad3051-9df2-4c54-9684-e8262a133af8), via openFDA; the full label on DailyMed
What does the phenytoin label say about lurasidone?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name lurasidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lurasidone | Phenytoin | |
|---|---|---|
| Labeled for | Schizophrenia, Bipolar disorder, Depression | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.142 per tablet 20 mg tablet | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once