What the FDA labels say about taking them together
Lopinavir/ritonavir and nicardipine
Lopinavir/ritonavir's FDA label of July 23, 2026 names nicardipine in its drug interactions section; the nicardipine labels PlainMeds reads (2) do not name lopinavir/ritonavir. The lopinavir/ritonavir label: “Clinical monitoring of patients is recommended and a dose reduction of the dihydropyridine calcium channel blocker may be considered.”
Check it at the source: the lopinavir/ritonavir FDA label on DailyMed (effective July 23, 2026, AbbVie Inc.); the nicardipine FDA label on DailyMed (effective August 24, 2024, Hikma Pharmaceuticals USA Inc.).
What does the lopinavir/ritonavir label say about nicardipine?
Lopinavir/ritonavir label, drug interactionsConcomitant Drug Class/Drug Name: Dihydropyridine Calcium Channel Blockers: e.g. felodipine, nifedipine, nicardipine; Effect on Concentration of Lopinavir or Concomitant Drug: ↑ dihydropyridine calcium channel blockers; Clinical Comments: Clinical monitoring of patients is recommended and a dose reduction of the dihydropyridine calcium channel blocker may be considered.
Source: FDA drug label (Kaletra), AbbVie Inc., effective July 23, 2026 (SPL set 8290add3-4449-4e58-6c97-8fe1eec972e3), via openFDA; the full label on DailyMed
What does the nicardipine label say about lopinavir/ritonavir?
Nicardipine's label (effective August 24, 2024) and its 1 other brand-application label do not name lopinavir/ritonavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Nicardipine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective August 24, 2024 (SPL set 18fb1c2b-0c1e-436c-a5b6-d4840b5da228), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lopinavir/ritonavir | Nicardipine | |
|---|---|---|
| Labeled for | HIV | High blood pressure, Angina |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $4.46 per tablet 200-50 mg tablet | $1.12 per capsule 20 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once