Lisinopril and Amiloride Interaction
Drug interaction information between Lisinopril and Amiloride.
Lisinopril and Amiloride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lisinopril and Amiloride. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Both drugs make it harder for your kidneys to get rid of potassium. This can cause potassium to build up to unsafe levels in your blood.
FDA Label Information
Use of lisinopril with potassium-sparing diuretics (e.g., spironolactone, eplerenone, triamterene, or amiloride), potassium supplements, or potassium-containing salt substitutes may lead to significant increases in serum potassium.
Lisinopril Also Interacts With
- Hydrochlorothiazide major
- Aliskiren major
- Losartan minor
- Spironolactone minor
- Propranolol minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
What SPL severity band is on file for Lisinopril + Amiloride?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Amiloride has 19 labeled pairs on file vs Lisinopril's 15. In the minor band specifically: Lisinopril has 13 (also Losartan, Spironolactone, Propranolol, Lithium); Amiloride has 11 (also Indomethacin, Amlodipine/Valsartan, Enalapril, Hydrochlorothiazide).
What mechanism field is on file for Lisinopril and Amiloride?
Both drugs make it harder for your kidneys to get rid of potassium. This can cause potassium to build up to unsafe levels in your blood.
Lisinopril carries more major-labeled pairs than Amiloride
SPL source-record counts only. This page's band is minor · classes on file: Lisinopril (ACE Inhibitor); Amiloride (Potassium-Sparing Diuretic).
Lisinopril has 2 major-labeled pairs vs Amiloride's 1. This page itself is in the minor band, not the major band.
2 major · 0 moderate · 13 minor · 15 total
- Other minor peers for Lisinopril
- Losartan
- Spironolactone
- Propranolol
- Lithium
1 major · 7 moderate · 11 minor · 19 total
- Other minor peers for Amiloride
- Indomethacin
- Amlodipine/Valsartan
- Enalapril
- Hydrochlorothiazide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.