What the FDA labels say about taking them together
Amiodarone and liothyronine
Liothyronine's FDA label of June 4, 2026 names amiodarone in its drug interactions section; the amiodarone labels PlainMeds reads (2) do not name liothyronine. The liothyronine label: “Other drugs: Amiodarone; Amiodarone inhibits peripheral conversion of levothyroxine (T4) to triiodothyronine (T3) and may cause isolated biochemical changes in clinically euthyroid patients.”
Check it at the source: the amiodarone FDA label on DailyMed (effective December 9, 2025, Chartwell RX, LLC); the liothyronine FDA label on DailyMed (effective June 4, 2026, Mylan Pharmaceuticals Inc.).
What does the amiodarone label say about liothyronine?
Amiodarone's label (effective December 9, 2025) and its 1 other brand-application label do not name liothyronine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Amiodarone Hydrochloride), Chartwell RX, LLC, effective December 9, 2025 (SPL set 5520f11d-968d-4f4f-bf57-d14369c0d746), via openFDA; the full label on DailyMed
What does the liothyronine label say about amiodarone?
Liothyronine label, drug interactionsOther drugs: Amiodarone; Amiodarone inhibits peripheral conversion of levothyroxine (T4) to triiodothyronine (T3) and may cause isolated biochemical changes (increase in serum free-T4, and decreased or normal free-T3) in clinically euthyroid patients.
Source: FDA drug label (Liothyronine Sodium), NDA010379 (King Pharms), as published by Mylan Pharmaceuticals Inc., effective June 4, 2026 (SPL set 115a84c2-0126-4dd7-816e-1873875f1e49), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Amiodarone | Liothyronine | |
|---|---|---|
| Labeled for | n/a | Hypothyroidism |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.122 per tablet 200 mg tablet | $0.294 per tablet 25 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once