What the FDA labels say about taking them together
Linezolid and oxacillin
Linezolid's FDA label of June 19, 2026 names oxacillin in its warnings and precautions section; the oxacillin labels PlainMeds reads (2) do not name linezolid. The linezolid label: “… mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. …”
Check it at the source: the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.); the oxacillin FDA label on DailyMed (effective December 31, 2025, Onesource Specialty Pharma Limited).
What does the linezolid label say about oxacillin?
Linezolid label, warnings and precautionsImbalance in an Investigational Study in Patients With Catheter-Related Bloodstream Infections, Including Those With Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI 0.970, 2.098].
Zyvox label (Pharmacia & Upjohn Company LLC, July 9, 2026), warnings and precautionsInform patients of the increased risk of serotonin syndrome when ZYVOX is used concomitantly with serotonergic agents. 5.4 Mortality Imbalance in an Investigational Study in Patients with Catheter-Related Bloodstream Infections, Including Those with Catheter-Site Infections An imbalance in mortality was seen in patients treated with linezolid relative to vancomycin/dicloxacillin/oxacillin in an open-label study in seriously ill patients with intravascular catheter-related infections [78/363 (21.5%) vs. 58/363 (16.0%); odds ratio 1.426, 95% CI 0.970, 2.098].
Source: FDA drug label (Zyvox, NDA021131), Pharmacia & Upjohn Company LLC, effective July 9, 2026 (SPL set 3e5e9975-6f36-42e4-ab46-0e75dda83592), via openFDA
Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed
What does the oxacillin label say about linezolid?
Oxacillin's label (effective December 31, 2025) and its 1 other brand-application label do not name linezolid in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (oxacillin), Onesource Specialty Pharma Limited, effective December 31, 2025 (SPL set 4972ec74-1d9a-de9b-e063-6394a90af786), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Linezolid | Oxacillin | |
|---|---|---|
| Labeled for | Bacterial infections | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.44 per tablet 600 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once