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What the FDA labels say about taking them together

Linezolid and methamphetamine

Methamphetamine's FDA label of September 30, 2024 names linezolid in its contraindications section; the linezolid labels PlainMeds reads (3) do not name methamphetamine. The methamphetamine label: “• taking monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MAOIs, because of the risk of hypertensive crisis.”

Check it at the source: the linezolid FDA label on DailyMed (effective June 19, 2026, Hospira, Inc.); the methamphetamine FDA label on DailyMed (effective September 30, 2024, Hikma Pharmaceuticals USA Inc.).

What does the linezolid label say about methamphetamine?

Linezolid's label (effective June 19, 2026) and its 2 other brand-application labels do not name methamphetamine in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Linezolid), Hospira, Inc., effective June 19, 2026 (SPL set c401f1a8-cc37-461b-bfef-f2e156629bf8), via openFDA; the full label on DailyMed

What does the methamphetamine label say about linezolid?

Methamphetamine label, contraindications

• taking monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of the risk of hypertensive crisis [see Drug Interactions ( 7.1 )].

Source: FDA drug label (Methamphetamine Hydrochloride), Hikma Pharmaceuticals USA Inc., effective September 30, 2024 (SPL set 90c02ac6-e5e2-4c97-8c68-81e4e389a195), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

24Linezolid generic labelers
3Methamphetamine generic labelers
LinezolidMethamphetamine
Labeled forBacterial infectionsADHD
Boxed warningNoYes
Pharmacy cost (NADAC)$1.44 per tablet 600 mg tablet$5.10 per tablet 5 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?