What the FDA labels say about taking them together
Lidocaine and propranolol
Lidocaine's FDA label (Lidocaine Hydrochloride And Dextrose) of February 20, 2026 names propranolol in its drug interactions section, and propranolol's label names lidocaine too. The propranolol label: “The metabolism of lidocaine is inhibited by co-administration of propranolol, resulting in a 25% increase in lidocaine concentrations.”
Check it at the source: the lidocaine FDA label on DailyMed (effective May 13, 2024, Fresenius Kabi USA, LLC); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the lidocaine label say about propranolol?
Lidocaine Hydrochloride And Dextrose label (Baxter Healthcare Corporation, February 20, 2026), drug interactionsWhen lidocaine is administered with other antiarrhythmic drugs such as amiodarone, phenytoin, procainamide, propranolol or quinidine, the cardiac effects may be additive or antagonistic and toxic effects may be additive.
Source: FDA drug label (Lidocaine Hydrochloride And Dextrose, NDA018461), Baxter Healthcare Corporation, effective February 20, 2026 (SPL set f21512ea-c7c3-4766-b976-b2c0b5616bf0), via openFDA
Source: FDA drug label (Xylocaine MPF), Fresenius Kabi USA, LLC, effective May 13, 2024 (SPL set d5e0d06f-ba1e-44d4-aa89-39d6c146dc23), via openFDA; the full label on DailyMed
What does the propranolol label say about lidocaine?
Propranolol label, drug interactionsThe metabolism of lidocaine is inhibited by co-administration of propranolol, resulting in a 25% increase in lidocaine concentrations.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lidocaine | Propranolol | |
|---|---|---|
| Labeled for | Pain | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.154 per gram 5% ointment | $0.0493 per tablet 20 mg tablet |
| Shortage now | In shortage | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once