Levomilnacipran and Warfarin Interaction
Drug interaction information between Levomilnacipran and Warfarin.
Levomilnacipran and Warfarin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Levomilnacipran and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medicines together can make your blood thinner and increase the risk of serious bleeding. It changes how well your body can stop a bleed.
FDA Label Information
Examples: NSAIDs, aspirin, and warfarin Strong CYP3A4 Inhibitors Clinical Impact: Concomitant use of FETZIMA with strong CYP3A4 inhibitors increases levomilnacipran exposure [see Pharmacokinetics ( 12.3 )] .
Levomilnacipran Also Interacts With
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
- Buspirone minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Levomilnacipran + Warfarin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Levomilnacipran's 11. In the minor band specifically: Levomilnacipran has 7 (also Buspirone, Aspirin, Ketoconazole, Lithium); Warfarin has 133 (also Atorvastatin, Amlodipine, Omeprazole, Famotidine).
What mechanism field is on file for Levomilnacipran and Warfarin?
Taking these medicines together can make your blood thinner and increase the risk of serious bleeding. It changes how well your body can stop a bleed.
Warfarin carries more major-labeled pairs than Levomilnacipran
SPL source-record counts only. This page's band is minor · classes on file: Levomilnacipran (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Levomilnacipran's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 7 minor · 11 total
- Other minor peers for Levomilnacipran
- Buspirone
- Aspirin
- Ketoconazole
- Lithium
2 major · 28 moderate · 133 minor · 163 total
- Other minor peers for Warfarin
- Atorvastatin
- Amlodipine
- Omeprazole
- Famotidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.