What the FDA labels say about taking them together
Levoleucovorin and phenytoin
Levoleucovorin's FDA label of August 29, 2023 names phenytoin in its drug interactions section; the phenytoin labels PlainMeds reads (2) do not name levoleucovorin. The levoleucovorin label: “… in large amounts may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone and increase the frequency of seizures in susceptible children.”
Check it at the source: the levoleucovorin FDA label on DailyMed (effective August 29, 2023, Slate Run Pharmaceuticals); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the levoleucovorin label say about phenytoin?
Levoleucovorin label, drug interactionsDRUG INTERACTIONS 7.1 Effects of Leucovorin Products on Other Drugs Antiepileptic Drugs Folic acid in large amounts may counteract the antiepileptic effect of phenobarbital, phenytoin and primidone and increase the frequency of seizures in susceptible children.
Source: FDA drug label (LEVOLEUCOVORIN CALCIUM), Slate Run Pharmaceuticals, effective August 29, 2023 (SPL set 124bc214-62f8-40f9-a227-a35e2d1ff2a0), via openFDA; the full label on DailyMed
What does the phenytoin label say about levoleucovorin?
Phenytoin's label (effective October 15, 2024) and its 1 other brand-application label do not name levoleucovorin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levoleucovorin | Phenytoin | |
|---|---|---|
| Labeled for | Colorectal cancer | Seizures and epilepsy |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.145 per capsule 100 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once