What the FDA labels say about taking them together
Levofloxacin and sotalol
Levofloxacin's FDA label of July 10, 2024 names sotalol in its warnings and precautions section; the sotalol labels PlainMeds reads (3) do not name levofloxacin. The levofloxacin label: “… patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.”
Check it at the source: the levofloxacin FDA label on DailyMed (effective July 10, 2024, Lupin Pharmaceuticals, Inc.); the sotalol FDA label on DailyMed (effective December 16, 2024, Legacy Pharma USA, Inc.).
What does the levofloxacin label say about sotalol?
Levofloxacin label, warnings and precautionsLevofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.
Source: FDA drug label (Levofloxacin), Lupin Pharmaceuticals, Inc., effective July 10, 2024 (SPL set 4be13bd5-0c39-43c3-9232-b1226ccd4dbc), via openFDA; the full label on DailyMed
What does the sotalol label say about levofloxacin?
Sotalol's label (effective December 16, 2024) and its 2 other brand-application labels do not name levofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (BETAPACE), Legacy Pharma USA, Inc., effective December 16, 2024 (SPL set a6a7702f-36c9-45db-b640-453dc324baee), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Levofloxacin | Sotalol | |
|---|---|---|
| Labeled for | Bacterial infections, Urinary tract infections | Atrial fibrillation |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.259 per tablet 750 mg tablet | $0.0707 per tablet 80 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once