Lemborexant and Rifampin Interaction
Drug interaction information between Lemborexant and Rifampin.
Lemborexant and Rifampin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lemborexant and Rifampin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin speeds up the process of clearing lemborexant from your system. This means the sleep medicine may not work as well as it should to help you sleep.
FDA Label Information
Examples: Strong CYP3A inducers: rifampin, carbamazepine, St.
Lemborexant Also Interacts With
- Fluconazole moderate
- Voriconazole moderate
- Bupropion minor
- Verapamil minor
- Carbamazepine minor
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Lemborexant + Rifampin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Lemborexant's 11. In the minor band specifically: Lemborexant has 9 (also Bupropion, Verapamil, Carbamazepine, Clarithromycin); Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide).
What mechanism field is on file for Lemborexant and Rifampin?
Rifampin speeds up the process of clearing lemborexant from your system. This means the sleep medicine may not work as well as it should to help you sleep.
Rifampin carries more major-labeled pairs than Lemborexant
SPL source-record counts only. This page's band is minor · classes on file: Lemborexant (Orexin Receptor Antagonist); Rifampin (Rifamycin Antibiotic).
Rifampin has 8 major-labeled pairs vs Lemborexant's 0. This page itself is in the minor band, not the major band.
0 major · 2 moderate · 9 minor · 11 total
- Other minor peers for Lemborexant
- Bupropion
- Verapamil
- Carbamazepine
- Clarithromycin
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.