Itraconazole · more major-labeled pairs than Lemborexant
SPL labels Lemborexant + Itraconazole as minor; Lemborexant 9 / Itraconazole 77 in that band.
Mechanism on file: Itraconazole stops the body from breaking down lemborexant normally. This leads to higher levels of the sleep medicine in your blood, which could increase daytime sleepiness.
FDA SPL severity: Minor
Lemborexant + Itraconazole · SPL mechanism field
Itraconazole stops the body from breaking down lemborexant normally. This leads to higher levels of the sleep medicine in your blood, which could increase daytime sleepiness.
Minor band excerpt · Lemborexant with Itraconazole
Examples: Strong CYP3A inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine Strong and Moderate CYP3A Inducers Clinical Impact: Concomitant use with a strong or moderate CYP3A inducer decreases lemborexant exposure, which may reduce DAYVIGO efficacy [see Clinical Pharmacology ( 12.3 )].
Lemborexant · 9 minor + 11 total pairs
- Bupropion minor
- Carbamazepine minor
- Chlorzoxazone minor
- Clarithromycin minor
Itraconazole · 19 major-labeled pairs (vs Lemborexant's 0)
- Apixaban minor
- Aprepitant minor
- Aripiprazole minor
- Bazedoxifene/Conjugated Estrogens minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.