What the FDA labels say about taking them together
Chlorzoxazone and lemborexant
Lemborexant's FDA label of February 24, 2025 names chlorzoxazone in its drug interactions section; the chlorzoxazone label PlainMeds reads does not name lemborexant. The lemborexant label: “Concomitant use with a strong, moderate, or weak CYP3A inhibitor increases lemborexant AUC and C max which may increase the risk of DAYVIGO adverse reactions.”
Check it at the source: the chlorzoxazone FDA label on DailyMed (effective September 5, 2023, Aurobindo Pharma Limited); the lemborexant FDA label on DailyMed (effective February 24, 2025, Eisai Inc.).
What does the chlorzoxazone label say about lemborexant?
Chlorzoxazone's label (effective September 5, 2023) does not name lemborexant in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (CHLORZOXAZONE), Aurobindo Pharma Limited, effective September 5, 2023 (SPL set 52d3aa2c-f88f-4de7-b5ae-df8a46e94879), via openFDA; the full label on DailyMed
What does the lemborexant label say about chlorzoxazone?
Lemborexant label, drug interactionsStrong, Moderate, and Weak CYP3A Inhibitors Clinical Impact: Concomitant use with a strong, moderate, or weak CYP3A inhibitor increases lemborexant AUC and C max which may increase the risk of DAYVIGO adverse reactions. … inhibitors: itraconazole, clarithromycin Moderate CYP3A inhibitors: fluconazole, verapamil Weak CYP3A inhibitors: chlorzoxazone, ranitidine
Source: FDA drug label (DAYVIGO), Eisai Inc., effective February 24, 2025 (SPL set 7074cb65-77b3-45d2-8e8d-da8dc0f70bfd), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorzoxazone | Lemborexant | |
|---|---|---|
| Labeled for | Muscle spasms and spasticity | Insomnia |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.210 per tablet 500 mg tablet | $11.57 per tablet 10 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once