What the FDA labels say about taking them together
Digoxin and ledipasvir/sofosbuvir
Ledipasvir/sofosbuvir's FDA label of December 26, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name ledipasvir/sofosbuvir. The ledipasvir/sofosbuvir label: “Coadministration of HARVONI with digoxin may increase the concentration of digoxin. Therapeutic concentration monitoring of digoxin is recommended when coadministered with HARVONI.”
Check it at the source: the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.); the ledipasvir/sofosbuvir FDA label on DailyMed (effective December 26, 2024, Gilead Sciences, Inc).
What does the digoxin label say about ledipasvir/sofosbuvir?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name ledipasvir/sofosbuvir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
What does the ledipasvir/sofosbuvir label say about digoxin?
Ledipasvir/sofosbuvir label, drug interactionsConcomitant Drug Class/Drug Name: digoxin; Effect on Concentration ↓ = decrease, ↑ = increase: ↑ digoxin; Clinical Comment: Coadministration of HARVONI with digoxin may increase the concentration of digoxin. Therapeutic concentration monitoring of digoxin is recommended when coadministered with HARVONI.
Source: FDA drug label (Harvoni), Gilead Sciences, Inc, effective December 26, 2024 (SPL set f4ec77e4-bae8-4db0-b3d5-bde09c5fa075), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Digoxin | Ledipasvir/sofosbuvir | |
|---|---|---|
| Labeled for | Heart failure, Atrial fibrillation | Hepatitis C |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.133 per tablet 125 mcg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once