What the FDA labels say about taking them together
Lasmiditan and propranolol
Lasmiditan's FDA label of January 8, 2026 names propranolol in its drug interactions section; the propranolol labels PlainMeds reads (4) do not name lasmiditan. The lasmiditan label: “In a drug interaction study, addition of a single 200 mg dose of REYVOW to propranolol decreased heart rate by an additional 5 beats per minute compared to propranolol alone, for a mean maximum of 19 beats per minute.”
Check it at the source: the lasmiditan FDA label on DailyMed (effective January 8, 2026, Eli Lilly and Company); the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.).
What does the lasmiditan label say about propranolol?
Lasmiditan label, drug interactionsIn a drug interaction study, addition of a single 200 mg dose of REYVOW to propranolol decreased heart rate by an additional 5 beats per minute compared to propranolol alone, for a mean maximum of 19 beats per minute.
Source: FDA drug label (Reyvow), Eli Lilly and Company, effective January 8, 2026 (SPL set aea3358c-ff41-4490-9e6d-c7bf7b3de13f), via openFDA; the full label on DailyMed
What does the propranolol label say about lasmiditan?
Propranolol's label (effective January 15, 2026) and its 3 other brand-application labels do not name lasmiditan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lasmiditan | Propranolol | |
|---|---|---|
| Labeled for | Migraine | High blood pressure, Angina, Atrial fibrillation, Migraine |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $88.77 per tablet 100 mg tablet | $0.0493 per tablet 20 mg tablet |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once