Lansoprazole and Voriconazole Interaction
Drug interaction information between Lansoprazole and Voriconazole.
Lansoprazole and Voriconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Lansoprazole and Voriconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Voriconazole can stop your body from breaking down lansoprazole as quickly as it should. This can cause the amount of lansoprazole in your blood to increase.
FDA Label Information
Intervention : Voriconazole : See prescribing information.
Lansoprazole Also Interacts With
- Amoxicillin major
- Clarithromycin major
- Rifampin moderate
- Tacrolimus Topical moderate
- Warfarin minor
Voriconazole Also Interacts With
- Norethindrone major
- Rifampin major
- Lurasidone major
- Pimozide major
- Ivabradine major
Frequently Asked Questions
What SPL severity band is on file for Lansoprazole + Voriconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Voriconazole has 50 labeled pairs on file vs Lansoprazole's 14. In the minor band specifically: Lansoprazole has 10 (also Warfarin, Methotrexate, Ketoconazole, Itraconazole); Voriconazole has 33 (also Omeprazole, Ibuprofen, Alprazolam, Oxycodone).
What mechanism field is on file for Lansoprazole and Voriconazole?
Voriconazole can stop your body from breaking down lansoprazole as quickly as it should. This can cause the amount of lansoprazole in your blood to increase.
Voriconazole carries more major-labeled pairs than Lansoprazole
SPL source-record counts only. This page's band is minor · classes on file: Lansoprazole (Proton Pump Inhibitor (PPI)); Voriconazole (Azole Antifungal).
Voriconazole has 8 major-labeled pairs vs Lansoprazole's 2. This page itself is in the minor band, not the major band.
2 major · 2 moderate · 10 minor · 14 total
- Other minor peers for Lansoprazole
- Warfarin
- Methotrexate
- Ketoconazole
- Itraconazole
8 major · 9 moderate · 33 minor · 50 total
- Other minor peers for Voriconazole
- Omeprazole
- Ibuprofen
- Alprazolam
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.