What the FDA labels say about taking them together
Lansoprazole and voriconazole
Lansoprazole's FDA label of June 24, 2025 names voriconazole in its drug interactions (prescription label) section; voriconazole's label does not name lansoprazole itself but warns about its class (Proton pump inhibitors (PPIs)). The lansoprazole label: “Increased exposure of lansoprazole is expected when used concomitantly with strong inhibitors.”
Check it at the source: the lansoprazole FDA label on DailyMed (effective June 24, 2025, L. Perrigo Company); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the lansoprazole label say about voriconazole?
Lansoprazole label, drug interactions (prescription label)CYP2C19 or CYP3A4 Inhibitors Clinical Impact: Increased exposure of lansoprazole is expected when used concomitantly with strong inhibitors. Intervention: Voriconazole: See prescribing information.
Source: FDA drug label (Prevacid 24 HR), L. Perrigo Company, effective June 24, 2025 (SPL set 205c9c1e-b422-4e86-a4b0-714b608adc19), via openFDA; the full label on DailyMed
What does the voriconazole label say about lansoprazole?
Voriconazole's label does not name lansoprazole itself; it warns about its class (Proton pump inhibitors (PPIs)):
Voriconazole label, drug interactionsThe metabolism of other proton pump inhibitors that are CYP2C19 substrates may also be inhibited by voriconazole and may result in increased plasma concentrations of other proton pump inhibitors.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Lansoprazole | Voriconazole | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.106 per capsule 30 mg capsule | $1.88 per tablet 200 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once