What the FDA labels say about taking them together
Labetalol and nitroglycerin
Labetalol's FDA label of March 2, 2026 names nitroglycerin in its drug interactions section; nitroglycerin's label does not name labetalol itself but warns about its class (Beta blockers). The labetalol label: “DRUG INTERACTIONS Beta blockers antagonize the bronchodilator effect of beta-receptor agonists. Increase hypotension may occur with halothane anesthesia. Nitroglycerin may result in additional hypotensive effects.”
Check it at the source: the labetalol FDA label on DailyMed (effective March 2, 2026, Zydus Pharmaceuticals USA Inc.); the nitroglycerin FDA label on DailyMed (effective February 15, 2023, Viatris Specialty LLC).
What does the labetalol label say about nitroglycerin?
Labetalol label, drug interactionsIf labetalol hydrochloride is used with nitroglycerin in patients with angina pectoris, additional antihypertensive effects may occur.
Labetalol Hydrochloride label (Hikma Pharmaceuticals USA Inc., December 19, 2025), drug interactionsDRUG INTERACTIONS Beta blockers antagonize the bronchodilator effect of beta-receptor agonists. ( 7.1 ) Increase hypotension may occur with halothane anesthesia. ( 7.2 ) Nitroglycerin may result in additional hypotensive effects.
Source: FDA drug label (Labetalol Hydrochloride, NDA213330), Hikma Pharmaceuticals USA Inc., effective December 19, 2025 (SPL set 99a715a0-4579-410c-b102-7ef6fab8db55), via openFDA
Source: FDA drug label (Labetalol Hydrochloride), Zydus Pharmaceuticals USA Inc., effective March 2, 2026 (SPL set 5942a5a8-c3c1-4ecb-921e-9bc92393bdf8), via openFDA; the full label on DailyMed
What does the nitroglycerin label say about labetalol?
Nitroglycerin's label does not name labetalol itself; it warns about its class (Beta blockers):
Nitroglycerin label, drug interactionsThe vasodilating effects of nitroglycerin may be additive with those of antihypertensives (e.g., beta-blockers, calcium channel blockers and tricyclic antidepressants) and may cause increased hypotensive effects..
Nitroglycerin label, drug interactionsPatients receiving antihypertensive drugs, beta-adrenergic blockers, and other nitrates should be observed for possible additive hypotensive effects when using RECTIV.
Source: FDA drug label (Nitrostat), Viatris Specialty LLC, effective February 15, 2023 (SPL set 9a52da75-d0af-4237-96c0-0b12adfa8636), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Labetalol | Nitroglycerin | |
|---|---|---|
| Labeled for | High blood pressure | Angina, High blood pressure, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.215 per tablet 300 mg tablet | $0.127 per tablet 0.4 mg tablet sl |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once