What the FDA labels say about taking them together
Labetalol and nicotine
Nicotine's FDA label of July 25, 2024 names labetalol in its drug interactions (prescription label) section; the labetalol labels PlainMeds reads (2) do not name nicotine. The nicotine label: “Adrenergic antagonists (e.g. prazosin, labetalol) Decrease in circulating catecholamines with smoking cessation.”
Check it at the source: the labetalol FDA label on DailyMed (effective March 2, 2026, Zydus Pharmaceuticals USA Inc.); the nicotine FDA label on DailyMed (effective July 25, 2024, Dr. Reddys Laboratories Inc.).
What does the labetalol label say about nicotine?
Labetalol's label (effective March 2, 2026) and its 1 other brand-application label do not name nicotine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Labetalol Hydrochloride), Zydus Pharmaceuticals USA Inc., effective March 2, 2026 (SPL set 5942a5a8-c3c1-4ecb-921e-9bc92393bdf8), via openFDA; the full label on DailyMed
What does the nicotine label say about labetalol?
Nicotine label, drug interactions (prescription label)Adrenergic antagonists (e.g. prazosin, labetalol) Decrease in circulating catecholamines with smoking cessation.
Source: FDA drug label (Nicotine transdermal system), Dr. Reddys Laboratories Inc., effective July 25, 2024 (SPL set e2391b29-9bac-fc09-f2a5-a3370bc4e2c3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Labetalol | Nicotine | |
|---|---|---|
| Labeled for | High blood pressure | Quitting smoking |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.215 per tablet 300 mg tablet | $1.87 per patch 21 mg/24hr patch |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once