What the FDA labels say about taking them together
Hydrochlorothiazide and ketoprofen
Ketoprofen's FDA label of February 15, 2026 names hydrochlorothiazide in its drug interactions section; hydrochlorothiazide's label does not name ketoprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)).
Check it at the source: the hydrochlorothiazide FDA label on DailyMed (effective June 12, 2026, Leading Pharma, LLC); the ketoprofen FDA label on DailyMed (effective February 15, 2026, Misemer Pharmaceuticals, Inc.).
What does the hydrochlorothiazide label say about ketoprofen?
Hydrochlorothiazide's label does not name ketoprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Hydrochlorothiazide label, drug interactionsNon-steroidal anti-inflammatory drugs - In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics.
Hydrochlorothiazide label, drug interactionsNon-steroidal anti-inflammatory drugs - In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. When hydrochlorothiazide and non-steroidal anti-inflammatory agents are used concomitantly, the patients should be observed closely to determine if the desired effect of the diuretic is obtained.
Source: FDA drug label (HYDROCHLOROTHIAZIDE), Leading Pharma, LLC, effective June 12, 2026 (SPL set 8c868894-667e-4a51-906a-838d63e420ba), via openFDA; the full label on DailyMed
What does the ketoprofen label say about hydrochlorothiazide?
Ketoprofen label, drug interactionsHydrochlorothiazide, given concomitantly with ketoprofen, produces a reduction in urinary potassium and chloride excretion compared to hydrochlorothiazide alone.
Source: FDA drug label (Ketoprofen), Misemer Pharmaceuticals, Inc., effective February 15, 2026 (SPL set d0f47ab6-29ff-df07-e053-2a95a90a2b51), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Hydrochlorothiazide | Ketoprofen | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Osteoarthritis, Rheumatoid arthritis, Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0115 per tablet 25 mg tablet | $6.46 per capsule 200 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once