What the FDA labels say about taking them together
Aspirin and ketoprofen
Ketoprofen's FDA label of February 15, 2026 names aspirin in its contraindications section; aspirin's label does not name ketoprofen itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The ketoprofen label: “Aspirin Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from …”
Check it at the source: the aspirin FDA label on DailyMed (effective September 9, 2025); the ketoprofen FDA label on DailyMed (effective February 15, 2026, Misemer Pharmaceuticals, Inc.).
What does the aspirin label say about ketoprofen?
Aspirin's label does not name ketoprofen itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Aspirin label, warningsThis product contains an NSAID, which may cause severe stomach bleeding.
Aspirin label, warningsThe chance is higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) have 3 or more alcohol drinks every day while using this product take more or for a longer time than directed
Source: FDA drug label (Medique Products Aspirin), Unifirst First Aid Corporation, effective September 9, 2025 (SPL set 9b28fed0-a993-ca72-e053-2995a90ac7fd), via openFDA; the full label on DailyMed
What does the ketoprofen label say about aspirin?
Ketoprofen label, contraindicationsKetoprofen capsules USP should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs.
Ketoprofen label, drug interactionsAspirin Ketoprofen does not alter aspirin absorption; however, in a study of 12 normal subjects, concurrent administration of aspirin decreased ketoprofen protein binding and increased ketoprofen plasma clearance from 0.07 L/kg/h without aspirin to 0.11 L/kg/h with aspirin.
Ketoprofen label, warningsThere is no consistent evidence that concurrent use of aspirin mitigates the increased risk of serious CV thrombotic events associated with NSAID use.
Ketoprofen label, warnings and precautionsThe use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm which can be fatal.
Source: FDA drug label (Ketoprofen), Misemer Pharmaceuticals, Inc., effective February 15, 2026 (SPL set d0f47ab6-29ff-df07-e053-2a95a90a2b51), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Aspirin | Ketoprofen | |
|---|---|---|
| Labeled for | Pain, Cough and cold, Fever | Osteoarthritis, Rheumatoid arthritis, Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.0142 per tablet 81 mg tablet | $6.46 per capsule 200 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once