What the FDA labels say about taking them together
Ketoconazole and ropivacaine
Ropivacaine's FDA label of August 6, 2024 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name ropivacaine.
Check it at the source: the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC); the ropivacaine FDA label on DailyMed (effective August 6, 2024, Fresenius Kabi USA, LLC).
What does the ketoconazole label say about ropivacaine?
Ketoconazole's label (effective January 28, 2026) does not name ropivacaine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
What does the ropivacaine label say about ketoconazole?
Ropivacaine label, drug interactionsCoadministration of a selective and potent inhibitor of CYP3A4, ketoconazole (100 mg bid for 2 days with ropivacaine infusion administered 1 hour after ketoconazole) caused a 15% reduction in in vivo plasma clearance of ropivacaine.
Source: FDA drug label (Naropin), Fresenius Kabi USA, LLC, effective August 6, 2024 (SPL set 23d2d448-a744-4877-9f2d-7e57c198da89), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ketoconazole | Ropivacaine | |
|---|---|---|
| Labeled for | Fungal infections | Pain |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.249 per gram 2% cream | n/a |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once