What the FDA labels say about taking them together
Ivacaftor/lumacaftor and sertraline
Ivacaftor/lumacaftor's FDA label of March 24, 2026 names sertraline in its drug interactions section; the sertraline labels PlainMeds reads (3) do not name ivacaftor/lumacaftor. The ivacaftor/lumacaftor label: “Concomitant use of ORKAMBI may reduce the exposure and effectiveness of citalopram, escitalopram, and sertraline.”
Check it at the source: the ivacaftor/lumacaftor FDA label on DailyMed (effective March 24, 2026, Vertex Pharmaceuticals Incorporated); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the ivacaftor/lumacaftor label say about sertraline?
Ivacaftor/lumacaftor label, drug interactionsConcomitant use of ORKAMBI may reduce the exposure and effectiveness of citalopram, escitalopram, and sertraline.
Source: FDA drug label (ORKAMBI), Vertex Pharmaceuticals Incorporated, effective March 24, 2026 (SPL set 3fc1c40e-cfac-47a1-9e1a-61ead3570600), via openFDA; the full label on DailyMed
What does the sertraline label say about ivacaftor/lumacaftor?
Sertraline's label (effective August 8, 2023) and its 2 other brand-application labels do not name ivacaftor/lumacaftor in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ivacaftor/lumacaftor | Sertraline | |
|---|---|---|
| Labeled for | n/a | Depression, Anxiety |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once