What the FDA labels say about taking them together
Itraconazole and phenytoin
Itraconazole's FDA label of July 13, 2026 names phenytoin in its drug interactions section, and phenytoin's label names itraconazole too. The itraconazole label: “Anticonvulsants Phenobarbital Phenytoin Not recommended 2 weeks before and during TOLSURA treatment.”
Check it at the source: the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.); the phenytoin FDA label on DailyMed (effective October 15, 2024, Mylan Pharmaceuticals Inc.).
What does the itraconazole label say about phenytoin?
Itraconazole label, drug interactionsAnticonvulsants Phenobarbital Phenytoin Not recommended 2 weeks before and during SPORANOX ® treatment.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
What does the phenytoin label say about itraconazole?
Phenytoin label, drug interactionsInteracting Agent: Azoles; Examples: Fluconazole, ketoconazole, itraconazole, miconazole, voriconazole
Source: FDA drug label (Phenytek), Mylan Pharmaceuticals Inc., effective October 15, 2024 (SPL set 0f94c791-8b07-4b41-927e-c9f28bec5f60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Itraconazole | Phenytoin | |
|---|---|---|
| Labeled for | Fungal infections | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.910 per capsule 100 mg capsule | $0.145 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once