Itraconazole and Eplerenone Interaction
Drug interaction information between Itraconazole and Eplerenone.
Itraconazole and Eplerenone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Itraconazole and Eplerenone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole prevents your body from processing eplerenone, which can cause the diuretic to reach toxic levels in your blood.
FDA Label Information
Diuretics Eplerenone Finerenone Contraindicated during and 2 weeks after itraconazole treatment.
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Eplerenone Also Interacts With
- Fluconazole major
- Verapamil major
- Erythromycin major
- Nirmatrelvir/Ritonavir major
- Lithium minor
Frequently Asked Questions
What SPL severity band is on file for Itraconazole + Eplerenone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Eplerenone's 12. In the major band specifically: Itraconazole has 19 (also Isavuconazonium, Lurasidone, Pimozide, Methadone); Eplerenone has 5 (also Fluconazole, Verapamil, Erythromycin, Nirmatrelvir/Ritonavir).
What mechanism field is on file for Itraconazole and Eplerenone?
Itraconazole prevents your body from processing eplerenone, which can cause the diuretic to reach toxic levels in your blood.
Itraconazole carries more major-labeled pairs than Eplerenone
SPL source-record counts only. This page's band is major · classes on file: Itraconazole (Azole Antifungal); Eplerenone (Aldosterone Antagonist).
Itraconazole has 19 major-labeled pairs vs Eplerenone's 5.
19 major · 20 moderate · 77 minor · 116 total
- Other major peers for Itraconazole
- Isavuconazonium
- Lurasidone
- Pimozide
- Methadone
5 major · 0 moderate · 7 minor · 12 total
- Other major peers for Eplerenone
- Fluconazole
- Verapamil
- Erythromycin
- Nirmatrelvir/Ritonavir
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.