What the FDA labels say about taking them together
Fentanyl and isradipine
Isradipine's FDA label of November 30, 2023 names fentanyl in its drug interactions section; the fentanyl labels PlainMeds reads (2) do not name isradipine. The isradipine label: “Fentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker.”
Check it at the source: the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.); the isradipine FDA label on DailyMed (effective November 30, 2023, Teva Pharmaceuticals USA, Inc.).
What does the fentanyl label say about isradipine?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name isradipine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
What does the isradipine label say about fentanyl?
Isradipine label, drug interactionsFentanyl Anesthesia: Severe hypotension has been reported during fentanyl anesthesia with concomitant use of a beta blocker and a calcium channel blocker.
Source: FDA drug label (Isradipine), Teva Pharmaceuticals USA, Inc., effective November 30, 2023 (SPL set bf3425e0-428d-4bdb-ac9a-3b9d483df83a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fentanyl | Isradipine | |
|---|---|---|
| Labeled for | Pain | High blood pressure |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $1.79 per mL 100 mcg/2 mL vial | $1.70 per capsule 5 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once