What the FDA labels say about taking them together
Isotretinoin and sarecycline
Sarecycline's FDA label of June 5, 2024 names isotretinoin in its drug interactions section; the isotretinoin labels PlainMeds reads (2) do not name sarecycline. The sarecycline label: “Drugs on SEYSARA Oral Retinoids Tetracyclines may cause increased intracranial pressure as do oral retinoids, including isotretinoin and acitretin.”
Check it at the source: the isotretinoin FDA label on DailyMed (effective August 19, 2026, Sun Pharmaceutical Industries, Inc.); the sarecycline FDA label on DailyMed (effective June 5, 2024, Almirall, LLC).
What does the isotretinoin label say about sarecycline?
Isotretinoin's label (effective August 19, 2026) and its 1 other brand-application label do not name sarecycline in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Absorica LD), Sun Pharmaceutical Industries, Inc., effective August 19, 2026 (SPL set 3ef0cff8-19c1-4441-b780-fca6c7ee1615), via openFDA; the full label on DailyMed
What does the sarecycline label say about isotretinoin?
Sarecycline label, drug interactionsDrugs on SEYSARA Oral Retinoids Tetracyclines may cause increased intracranial pressure as do oral retinoids, including isotretinoin and acitretin [see Warnings and Precautions ( 5.4 )].
Sarecycline label, warnings and precautionsConcomitant use of isotretinoin and SEYSARA should be avoided because isotretinoin, a systemic retinoid, is also known to cause intracranial hypertension [see Drug Interactions ( 7.1 )].
Source: FDA drug label (Seysara), Almirall, LLC, effective June 5, 2024 (SPL set b200957c-3004-4988-be97-9fd619a83649), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isotretinoin | Sarecycline | |
|---|---|---|
| Labeled for | Acne | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $11.94 per capsule 10 mg capsule | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once