What the FDA labels say about taking them together
Isocarboxazid and sertraline
Isocarboxazid's FDA label of April 21, 2026 names sertraline in its contraindications section, and sertraline's label names isocarboxazid too. The sertraline label: “The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome.”
Check it at the source: the isocarboxazid FDA label on DailyMed (effective April 21, 2026, Lifsa Drugs LLC); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the isocarboxazid label say about sertraline?
Isocarboxazid label, contraindicationsAt least 2 weeks should be allowed after stopping sertraline (Zoloft ® , Pfizer) or paroxetine (Paxil ® , SmithKline Beecham Pharmaceuticals) before starting Marplan.
Source: FDA drug label (MARPLAN), Lifsa Drugs LLC, effective April 21, 2026 (SPL set 95fde749-44ad-4668-86c4-0ff17bca0074), via openFDA; the full label on DailyMed
What does the sertraline label say about isocarboxazid?
Sertraline label, drug interactionsMonoamine Oxidase Inhibitors (MAOIs) Clinical Impact: The concomitant use of SSRIs including ZOLOFT and MAOIs increases the risk of serotonin syndrome. Intervention: ZOLOFT is contraindicated in patients taking MAOIs, including MAOIs such as linezolid or intravenous methylene blue [See,, ]. Examples: selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Isocarboxazid | Sertraline | |
|---|---|---|
| Labeled for | Depression | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0507 per tablet 100 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once