What the FDA labels say about taking them together
Irinotecan and voriconazole
Irinotecan's FDA label of May 12, 2026 names voriconazole in its drug interactions section; the voriconazole labels PlainMeds reads (3) do not name irinotecan. The irinotecan label: “Co-administration of ONIVYDE with other inhibitors of CYP3A4 or UGT1A1 may increase systemic exposure to irinotecan or SN-38.”
Check it at the source: the irinotecan FDA label on DailyMed (effective May 12, 2026, Pharmacia & Upjohn Company LLC); the voriconazole FDA label on DailyMed (effective February 26, 2026, Roerig).
What does the irinotecan label say about voriconazole?
Irinotecan label, drug interactionsCoadministration of CAMPTOSAR with other inhibitors of CYP3A4 (e.g., clarithromycin, indinavir, itraconazole, lopinavir, nefazodone, nelfinavir, ritonavir, saquinavir, telaprevir, voriconazole) or UGT1A1 (e.g., atazanavir, gemfibrozil, indinavir) may increase systemic exposure to irinotecan or SN-38.
Source: FDA drug label (Onivyde, NDA207793), Ipsen Biopharmaceuticals, Inc., effective March 3, 2025 (SPL set c8b58efa-1820-48a4-b70d-62918fc4abfc), via openFDA
Source: FDA drug label (Camptosar), NDA020571 (Pfizer Inc), as published by Pharmacia & Upjohn Company LLC, effective May 12, 2026 (SPL set e518dfc6-7e93-4fee-a66c-51e1ab71c056), via openFDA; the full label on DailyMed
What does the voriconazole label say about irinotecan?
Voriconazole's label (effective February 26, 2026) and its 2 other brand-application labels do not name irinotecan in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VFEND), NDA021630 (Pf Prism Cv), as published by Roerig, effective February 26, 2026 (SPL set ce3ef5cf-3087-4d92-9d94-9eb8287228db), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Irinotecan | Voriconazole | |
|---|---|---|
| Labeled for | Colorectal cancer | Fungal infections |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $1.88 per tablet 200 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once