What the FDA labels say about taking them together
Ipratropium and tiotropium
Tiotropium's FDA label of November 10, 2025 names ipratropium in its contraindications section; the ipratropium labels PlainMeds reads (2) do not name tiotropium. The tiotropium label: “CONTRAINDICATIONS SPIRIVA RESPIMAT is contraindicated in patients with a hypersensitivity to tiotropium, ipratropium, or any component of this product.”
Check it at the source: the ipratropium FDA label on DailyMed (effective January 8, 2026, Lupin Pharmaceuticals, Inc.); the tiotropium FDA label on DailyMed (effective November 10, 2025, Boehringer Ingelheim Pharmaceuticals, Inc.).
What does the ipratropium label say about tiotropium?
Ipratropium's label (effective January 8, 2026) and its 1 other brand-application label do not name tiotropium in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (IPRATROPIUM BROMIDE), Lupin Pharmaceuticals, Inc., effective January 8, 2026 (SPL set 13a45df5-a8e3-41d6-91f4-773255b5a04b), via openFDA; the full label on DailyMed
What does the tiotropium label say about ipratropium?
Tiotropium label, contraindicationsCONTRAINDICATIONS SPIRIVA HANDIHALER is contraindicated in patients with a hypersensitivity to tiotropium, ipratropium, or any components of this product [see Warnings and Precautions (5.2) ].
Source: FDA drug label (Spiriva Respimat, NDA021936), Boehringer Ingelheim Pharmaceuticals, Inc., effective August 17, 2026 (SPL set 7b656b14-fcaa-2741-f6f0-e0be48971c02), via openFDA
Source: FDA drug label (Spiriva HandiHaler), Boehringer Ingelheim Pharmaceuticals, Inc., effective November 10, 2025 (SPL set 820839ef-e53d-47e8-a3b9-d911ff92e6a9), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ipratropium | Tiotropium | |
|---|---|---|
| Labeled for | COPD, Allergies, Cough and cold | COPD, Asthma |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.111 per mL 0.02% solution | $11.81 per capsule 18 mcg capsule-inhaler |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once